管理提醒： 本帖被 chenshuuu 执行加亮操作(2010-12-27)
Soap films cut grease with ease, but with just a dash of the ring-shaped polysaccharide cyclodextrin they can do even more: separate one mirror image of a all molecule from a mixture containing both (J. Am. Chem. Soc., DOI: 10.1021/ja109461r). Soap bubbles could become useful for chiral separations, which are important for purifying molecules such as drugs, pesticides, and their precursors.
Purnendu K. Dasgupta and colleagues at the University of Texas, Arlington, had previously found a way to make normally evanescent soap bubbles last for tens of minutes and detect low levels of gases (. Chem., DOI: 10.1021/ac052198h). While investigating how all molecules permeate their soap structures, they doped films of the detergent Triton-X-100 with α-cyclodextrin, a common player in chromatography. The researchers found that, by a factor of 1.6, more α(+)-pinene crossed the soap membrane than did its enantiomer. This happens because, compared to α(+)-pinene, α(-)-pinene gets held up longer in the soap film by binding to the cyclodextrin, the team says.
The soap membrane's 1.6-fold selectivity leaves room for improvement, says Mathias Ulbricht, who studies membranes as tools for separations at the University of Duiurg-Essen, in Germany. He suggests that the researchers could modify the species doped into the soap film as a chiral selector.
Chromatography expert Apryll M. Stalcup at the University of Cincinnati welcomes the new technique. Existing chiral separation techniques tend to be pricey, or aren't widely applicable, or both, she says. "This approach offers many advantages," she says, "including ability to be readily scaled up as well as ready recovery of the individual enantiomers and the chiral selector, which is often expensive."
