这项双盲、随机、安慰剂对照组研究共纳入311例亚洲结直肠腺癌患者，所有患者均通过内镜明确诊断。受试者服用阿司匹林或安慰剂100mg，每日1次，持续2年。研究者发现服用阿司匹林的患者复发风险降低。非吸烟患者服用阿司匹林后复发风险也降低，但是吸烟的结直肠腺癌患者服用阿司匹林后复发风险升高。
与之前的研究结果相一致，这项研究结果也表明阿司匹林能够减少结直肠癌复发。之前的研究是在西方人群中实施的，而这项研究却是集中调查阿司匹林在亚洲人群中的作用。
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In this double-blinded, randomized, placebo-controlled study, 311 Asian patients with colorectal adenomas and adenocarcinomas excised by endoscopy were assigned to receive aspirin 100 mg once daily or placebo for 2 years. Researchers found that patients receiving aspirin had reduced risk for recurrence. Aspirin use in nonokers also reduced risk but resulted in higher risk in okers. Similar to previous findings, results suggest that aspirin reduces tumor recurrence in patients with colorectal cancer. Previous studies investigated patient populations of Western countries, whereas this study focused on aspirin effect in an Asian population.
Gut
The Preventive Effects of Low-Dose Enteric-Coated Aspirin Tablets on the Development of Colorectal Tumours in Asian Patients: A Randomised Trial
Gut 2014 Nov 01;63(11)1755-1759, H Ishikawa, M Mutoh, S Suzuki, S Tokudome, Y Saida, T Abe, S Okamura, M Tajika, T Joh, S Tanaka, SE Kudo, T Matsuda, M Iimuro, T Yukawa, T Takayama, Y Sato, K Lee, S Kitamura, M Mizuno, Y Sano, N Gondo, K Sugimoto, M Kusunoki, C Goto, N Matsuura, T Sakai, K Wakabayashi
