关键信息
该项回顾性研究针对内窥镜筛查结果为阴性的中危患者进行了分析。研究者发现，与乙状结肠镜筛查相比，结肠镜筛查后患者结直肠癌(CRC)的校正风险比为0.42(95%CI，0.28~0.64;P<0.0001)，而且主要是近端肿瘤风险下降。此外，乙状结肠镜筛查组中，与非西班牙裔白人患者相比，非西班牙裔黑人患者筛查后CRC风险增加。
该研究提示，与乙状结肠镜筛查结果为阴性的患者相比，结肠镜筛查结果为阴性的患者CRC风险显著降低。作者指出，这项回顾性研究的局限性在于潜在的选择性偏倚。
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In a retrospective study of average-risk patients with anegative endoscopic screening examination, the adjusted hazard ratio ofpost-screening colorectal cancer (CRC) was 0.42 (95% CI, 0.28–0.64; P <.0001) for colonoscopy vssigmoidoscopy. Reduction of risk pertained primarilyto proximal tumors. In the sigmoidoscopy group, there was an increased risk forpost-screening CRC in non-Hispanic black patientsvs non-Hispanic whitepatients.
Patients who underwent a negative colonoscopy were at alower risk for post-screening CRC compared with those with a negativesigmoidoscopy. Potential selection bias represents a limitation of this retrospectivestudy.
