Encyclopedia of Controlled Drug Delivery (2-Volume Set) Editor: Edith Mathiowitz
About The Editor Dr. Mathiowitz, Associate Professor of Medical Science & Engineering and Director of the Graduate Program in Artificial Organs, Biomaterials, and Cellular Technology in the Department of Molecular Pharmacology and Biotechnology of Brown University, received her Ph.D. in the Department of Structural Chemistry at the Weizmann Institute. At MIT, she continued her research as a postdoctoral student under Dr. Robert Langer. Since then, Dr. Mathiowitz has been involved in research developing oral bioadhesive delivery systems for Proteins and genes, microencapsulation of proteins and genes, and tissue engineering of vascular grafts. She has published 90 papers, has 30 patents, and is a consultant to many biotech companies. She is also the founder of Spherics. A RI Biotech company.
Homepage:
http://research.brown.edu/myresearch/Edith_Mathiowitz Preface (前言)
The two-volume Encyclopedia of Controlled Drug Delivery will provide extensive, yet easily accessible, A-Z coverage of state-of-the-art topics in drug delivery systems. The encyclopedia can be used by research departments in industry, research institutes, universities, libraries, and consultants. The readers may range from undergraduate and graduate students to professional engineers, biologists, chemists, and medical researchers. In addition, research managers, as well as business venturers, will find this encyclopedia a very useful source of information. Scientists unfamiliar with the field of drug delivery will find a good introduction to the field, while experts will find the book to be a good, current source of information. The contents of these two volumes provide coverage of many aspects of drug delivery systems, including:
(1) The history and development of the field from 1975 to date;（药物控释发展史（1975~））
(2) Advantages and disadvantages of controlled release technology as compared to conventional delivery systems (pharmaceutical as well as veterinary applications)（药物控释与常规药物释放体系相比的优缺点）
(3) Detailed descriptions of the various systems for achieving controlled drug release, including nonerodible reservoir and matrix devices, bioerodible polymers, pendent drug substitutes, and ootic pumps（各种药物控释体系的详细描述）
(4) Pharmaceutical applications of drug delivery systems, approaches to achieve zerorelease kinetics, development of pulsatile delivery systems including approaches to develop selfregulated systems by using responsive hydrogels or encapsulated live cells（药物控释在制药学中的应用）
(5) Stabilization and release characterization of proteins（蛋白质的稳定及释放性质）
(6) Characterization of specific delivery systems such as oral, nasal, ocular, and other routes of administration（特定药物输送体系的性质）
(7) Methods to fabricate controlled delivery systems, including microencapsulation, liposome preparation, film casting, and membrane formation（药物控释体系的构筑方法）
(8) Factors affecting regulatory considerations
(9) Economic aspects of controlled drug delivery devices（药物控释设备的经济因素）
(10) Patents and other intellectual property rights in drug delivery（有关药物输送的专利及其他知识产权）
(11) Oligonucleotides and gene delivery（寡核苷酸以及基因治疗）
(12) Specific topics in polymer technology which are peculiar to drug delivery systems, including polymer synthesis, structure, morphology, amorphous polymers, glassy and rubbery states, polymer networks, and a variety of methods to characterize polymers and drug delivery systems.（药物控释体系中的聚合物技术）
The encyclopedia can easily be used as an advanced text or reference book for a drug delivery system course. It is written by some of the greatest experts and most diligent educators in the field. These volumes should constitute an important research reference tool, a desktop information resource, and supplementary reading for teaching professionals and their students.
Foreword（国际著名生物材料专家Robert Langer作序）
Drug delivery systems that can precisely control drug release rates or target drugs to a specific body site, although a relatively recent technology, have had an enormous medical and economic impact. New drug delivery systems impact nearly every branch of medicine and annual sales of these systems are far in excess of 10 billion dollars. However, to intelligently create new delivery systems or to understand how to evaluate existing ones, much knowledge is needed. Dr. Edith Mathiowitz of Brown University has, in this encyclopedia, successfully put together a remarkable amount of information to achieve that goal of knowledge.
The Encyclopedia of Controlled Drug Delivery provides an up-to-date ysis of critical areas in this promising field. New approaches in treating diseases such as alcoholi, cancer, heart disease, and infectious diseases are examined. Delivery of vaccines, contraceptive agents, anticalcification agents, orthopedic agents, and veterinary agents is discussed. Novel polymeric materials including polyanhydrides, chitosan polyesters, polyphosphates, polyphosphazenes, hydrogels, bioadhesive materials, and poly(ortho esters) are evaluated. Extensive characterization approaches including differential scanning calorimetry, gel permeation chromatography, spectroscopy, X-ray photoelectron spectroscopy, X-ray powder diffraction, and surface characterization are explored.
New areas related to drug delivery such as gene therapy, blood substitutes, food ingredients, and tissue engineering are discussed. An ysis of various routes of administration including parenteral, intravitreal, oral, rectal, ocular, nasal, buccal, vaginal, and the central nervous system is provided. Different controlled release designs such as ootic pumps, pendentchain systems, membrane systems, nanoparticles, and liposomes are examined. Finally, patents, regulatory issues, manufacturing approaches, economics, in vitro-in vivo correlations, pharmacokinetics, release kinetics, assays, diagnostics, and related issues are considered.
This encyclopedia is a very complete compendium of the stateoftheart of this burgeoning field and should be of considerable value for those who wish to enter it.
ROBERT LANGER
Massachusetts Institute of Technology
内容标题
A
Alcoholi and drug dependence, drug delivery to treat
B
Bioadhesive Drug delivery systems
Biodegradable Polymers: Poly(phosphoester)s（缺少此篇，希望虫友补充）
Biodegradable Polymers: Polyanhydrides
Biodegradable Polymers: Polyesters
Blood Substitutes: A Review of Clinical Trials
C
Calcification, drug delivery to prevent
Cancer, drug delivery to treat - local & systemic
Cancer, Drug Delivery to Treat - Prodrugs
Cardiovascular Drug Delivery Systems
Carrier-mediated transport, oral drug delivery
Central Nervous System, Drug Delivery to treat
Characterization of Delivery Systems, Differential Scanning Calorimetry
Characterization of delivery systems, Gel permeation chromatography
Characterization of delivery systems, Magnetic Resonance Techniques
Characterization of delivery systems, Microscopy
Characterization of delivery systems, Particle Sizing Techniques
Characterization of delivery systems, Surface ysis and controlled release systems
Characterization of Delivery Systems, XPS, SIMS and AFM ysis
Characterization of Delivery Systems, X-Ray Powder Diffraction
Characterization of delivery systems,Spectroscopy
Chemical Approaches to drug delivery
Coatings
D
Diagnostic Use of microspheres
E
Economic Aspects of Controlled Drug Delivery
F
Fabrication of Controlled-Delivery Devices
Fertility Control
Food and Drug Administration Requirements for Controlled Release Products
H
Hydrogels
I
Immunoisolated Cell Therapy
In vitro-In vivo correlation
Infectious Disease, Drug Delivery to Treat
Intelligent Drug Delivery systems
L
Liposomes
M
Microencapsulation
Microencapsulation for Gene Delivery
Mucosal drug delivery, buccal
Mucosal Drug Delivery, Intravitreal
Mucosal Drug Delivery, Nasal
Mucosal Drug Delivery, occular
Mucosal Drug Delivery, Vaginal Drug Delivery and Treatment Modalities
N
Nanoparticles
Non-degradable polymers for drug delivery
O
Oligonucleotide delivery
Oral Drug Delivery, all Intestine & Colon
Oral Drug Delivery, Traditional
P
Parenteral Drug Delivery Systems
Patents and Other Intellectual Property Rights in Drug Delivery
Pendent Drugs, release from polymers
Peptide and Protein Drug Delivery
Pharmacokinetics
Poly (Ortho Esters)
Polymeric Systems for Gene Delivery, Chitosan and PINC Systems
Protein Therapeutics for Skeletal Tissue Repair
Pumps (ootic)-Intro
Pumps/ Ootic - ALZET® system
Pumps/ Ootic-VITS Veterinary Implant
Pumps/Ootic - DUROS™ ootic implant for humans
Pumps/Ootic - Ruminal ootic bolus
R
Release Kinetics, Data Interpretation
Respiratory System Delivery
S
Synthetic Vascular Grafts and Controlled-Release Technology
T
Tissue-Implant Interface,Biological Resp. to Artificial Materials w/ Surface-Immobilized all peptides
Transdermal Drug Delivery, Electrical
Transdermal Drug Delivery, Passive
V
Vaccine Delivery
Veterinary Applications
下载地址
本部分内容设定了隐藏,需要回复后才能看到
