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Short term effects of atorvastatin on endothelial functions and oxidized LDL levels in patients with type 2 diabetes.
Endocr J. 2008 Oct;55(5):861-6.
OBJECTIVE: This study was designed in order to investigate the short term effects of atorvastatin on endothelial function and oxidized LDL (oxLDL) levels and to evaluate the association of endothelial dysfunction to oxLDL levels and inflammatory markers in type 2 diabetic patients. MATERIAL AND METHODS: Thirty type 2 diabetic and 11 healthy subjects with LDL levels between 100-160 mg/dl. without a history of cardiovascular event were included in the study. Both groups were matched with respect to age, gender, body mass indices and lipid levels. Flow- mediated dilatation (endothelium dependent, FMD) and nitroglycerine-induced dilatation (endothelium independent, NID) were measured in the brachial artery using high-resolution ultrasound in all participants and carotid artery intima media thickness (IMT) were also evaluated. OxLDL levels, lipid parameters, blood glucose, C-peptide, HbA1c and inflammatory markers including C-reactive protein (CRP), fibrinogen, erythrocyte sedimentation rate (ESR) were studied. Type 2 diabetic patients received 10 mg. Atorvastatin for 6 weeks and FMD and NID were reevaluated and oxLDL levels and inflammatory markers remeasured. RESULTS: Basal FMD, NID, IMT and oxLDL levels besides inflammatory markers were not significantly different between patients and controls. No correlation was found between inflammatory markers and FMD and NID. Only IMT correlated with fibrinogen levels obtained before treatment. In non-diabetics, IMT also correlated with oxLDL levels (p: 0.013). FMD and NID significantly improved after atorvastatin therapy ((7.62 +/- 7.6 vs. 12.65 +/- 7.8, p<0.001 and 18.22 +/- 9.57 vs. 21.43 +/- 9.6, p: 0.007, respectively). Atorvastatin significantly reduced oxLDL levels (57.85 +/- 10.33 vs. 44.36 +/- 6.34, p<0.001). CONCLUSION: Atorvastatin improves endothelial functions and reduces oxLDL levels in type 2 diabetics with average lipid levels in the short term and may have beneficial effects in the prevention of early atherosclerotic changes.

Short term effects of atorvastatin on endothelial functions and oxidized LDL levels in patients with type 2 diabetes.


阿托伐他汀对2型糖尿病患者内皮细胞功能及氧化型低密度脂蛋白水平的短期效应

OBJECTIVE: This study was designed in order to investigate the short term effects of atorvastatin on endothelial function and oxidized LDL (oxLDL) levels and to evaluate the association of endothelial dysfunction to oxLDL levels and inflammatory markers in type 2 diabetic patients.
目的:本实验是为了研究,阿托伐他汀对内皮功及低密度脂蛋白(oxLDL)水平影响和评价相关oxLDL代谢水平异常在2型糖尿病患者中的效果。

MATERIAL AND METHODS: Thirty type 2 diabetic and 11 healthy subjects with LDL levels between 100-160 mg/dl. without a history of cardiovascular event were included in the study. Both groups were matched with respect to age, gender, body mass indices and lipid levels. Flow- mediated dilatation (endothelium dependent, FMD) and nitroglycerine-induced dilatation (endothelium independent, NID) were measured in the brachial artery using high-resolution ultrasound in all participants and carotid artery intima media thickness (IMT) were also evaluated. OxLDL levels, lipid parameters, blood glucose, C-peptide, HbA1c and inflammatory markers including C-reactive protein (CRP), fibrinogen, erythrocyte sedimentation rate (ESR) were studied. Type 2 diabetic patients received 10 mg. Atorvastatin for 6 weeks and FMD and NID were reevaluated and oxLDL levels and inflammatory markers remeasured
材料和方法:选择低密度脂蛋白水平在100 - 160毫克/ dl不伴心血管疾病的30例2型糖尿病患者和11个健康的受试者。两组在年龄、性别、体重指数、血脂水平匹配。在肱动脉用超声 测所有参与者的FMD和NID 水平同时评估颈动脉内膜厚度、低密度脂蛋白水平OxL、DL水平、脂质参数、血糖、c -肽,血红蛋白和炎症标志物包括c反应蛋白(c)、纤维蛋白原、红血球沉降速率(ESR)。2型糖尿病患者用10毫克的阿托伐他汀治疗。阿托伐他汀治疗6周，再次评估FMD、 NID和 氧化型低密度脂蛋白水平。

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